Kettunen P. (2023) Vaskulär demens in “Boken om demenssjukdomar”, Liber. Book chapter in Swedish
Axelsson Andrén E, Kettunen P, Bjerke M, Rolstad S, Zetterberg H, Blennow K, Wallin A, Svensson J. (2023) Diagnostic Performance of Cerebrospinal Fluid Neurofilament Light Chain and Soluble Amyloid-β Protein Precursor β in the Subcortical Small Vessel Type of Dementia. J Alzheimers Dis. 96(4):1515-1528.
Melin J, Kettunen P, Wallin A, Pendrill L (2023) Entropy-based explanations of serial position and learning effects in ordinal responses to word list tests. Acta IMEKO
Öhman, F., Eckerström, M., Hessen, E., Espenes, J., Eliassen, I. V., Lorentzen, I. M., Stålhammar, J., Kettunen, P., Schöll, M., Fladby, T., Wallin, A., & Kirsebom, B. E. (2023). Demographically adjusted Rey-Osterrieth Complex Figure Test norms in a Swedish and Norwegian cohort aged 49-77 years and comparison with North American norms. Scandinavian journal of psychology. 65(2):168-178. doi: 10.1111/sjop.12966.
Larsson, S, Kettunen, P*, Carén, H* (2022). Orthotopic Transplantation of Human Paediatric High-Grade Glioma in Zebrafish Larvae. Brain sciences, 12(5), 625. *Equal author contribution
Andersson M, Roques JAC, Aliti GM, Ademar K, Sundh H, Sundell K, Ericson M, Kettunen P. (2022) Low Holding Densities Increase Stress Response and Aggression in Zebrafish. Biology. 11, 725.
Kettunen P, Bjerke M, Eckerström C, Jonsson M, Zetterberg H, Blennow K, Svensson J, Wallin A. (2022) Blood-brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein-β in patients with subcortical small-vessel disease. Alzheimers Dement (Amst). 14(1):e12296.
Jeppsson A, Bjerke M, Hellström P, Blennow K, Zetterberg H, Kettunen P, Wikkelsø C, Wallin A, Tullberg M. (2022) Shared CSF Biomarker Profile in Idiopathic Normal Pressure Hydrocephalus and Subcortical Small Vessel Disease. Front Neurol. 13:839307.
Xu J, Green R, Kim M, Lord J, Ebshiana A, Westwood S, Baird AL, Nevado-Holgado AJ, Shi L, Hye A, Snowden SG, Bos I, Vos SJB, Vandenberghe R, Teunissen CE, Kate MT, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck EE, Engelborghs S, Sleegers K, Bordet R, Rami L, Kettunen P, Tsolaki M, Verhey FRJ, Alcolea D, Lleó A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Proitsi P, Legido-Quigley C, on behalf of the European Medical Information Framework Consortium. (2021) Sex-Specific Metabolic Pathways Were Associated with Alzheimer’s Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort. Biomedicines. 9(11):1610
Andersson M, Kettunen P. (2021) Effects of Holding Density on the Welfare of Zebrafish: A Systematic Review. Zebrafish. (5):297-306.
Svensson J, Blomqvist M, Kettunen P, Eckerström C, Henricsson M, Jonsson M, Bjerke M, Månsson JE, Wallin A. (2021) Cerebrospinal Fluid Sulfatide Levels Lack Diagnostic Utility in the Subcortical Small Vessel Type of Dementia. J Alzheimers Dis. 2021;82(2):781-790.
Shi L, Winchester LM, Westwood S, Baird AL, Anand SN, Buckley NJ, Hye A, Ashton NJ, Bos I, Vos SJB, Kate MT, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lléo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Legido-Quigley C, Barkhof F, Andreasson U, Blennow K, Zetterberg H, Streffer J, Lill CM, Bertram L, Visser PJ, Kolb HC, Narayan VA, Lovestone S, Nevado-Holgado AJ. (2021) Replication study of plasma proteins relating to Alzheimer’s pathology. Alzheimers Dement. doi: 10.1002/alz.12322.
Minta K, Brinkmalm G, Portelius E, Johansson P, Svensson J, Kettunen P, Wallin A, Zetterberg H, Blennow K, Andreasson U. (2021) Brevican and Neurocan Peptides as Potential Cerebrospinal Fluid Biomarkers for Differentiation Between Vascular Dementia and Alzheimer’s Disease. J Alzheimers Dis. 79(2):729-741.
Eckerström C, Svensson J, Kettunen P, Jonsson M, Eckerström M. (2021) Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders. Alzheimers Dement (Amst). 13(1):e12031.
Hong S, Prokopenko D, Dobricic V, Kilpert F, Bos I, Vos SJB, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Cleynen I, Gabel S, Schaeverbeke J, Scheltens P, Teunissen CE, Niemantsverdriet E, Engelborghs S, Frisoni G, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Kettunen P, Wallin A, Lleó A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Sleegers K, Van Broeckhoven C, Ten Kate M, Barkhof F, Zetterberg H, Lovestone S, Streffer J, Wittig M, Franke A, Tanzi RE, Visser PJ, Bertram L. (2020) Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset. Translational Psychiatry. 10(1):403.
Shi L, Winchester LM, Liu BY, Killick R, Ribe EM, Westwood S, Baird AL, Buckley NJ, Hong S, Dobricic V, Kilpert F, Franke A, Kiddle S, Sattlecker M, Dobson R, Cuadrado A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Ten Kate M, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleó A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frölich L, Legido-Quigley C, Barkhof F, Blennow K, Rasmussen KL, Nordestgaard BG, Frikke-Schmidt R, Nielsen SF, Soininen H, Vellas B, Kloszewska I, Mecocci P, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Bertram L, Nevado-Holgado AJ, Lovestone S.(2020) Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer’s Disease Pathology. J Alzheimers Dis. 77(3):1353-1368.
Landin J, Hovey D, Xu B, Lagman D, Zettergren A, Larhammar D, Kettunen P*, Westberg L* (2020) Oxytocin Receptors Regulate Social Preference in Zebrafish. Scientific reports. Mar 25;10(1):5435. *Equal author contribution
Westwood S, Baird AL, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lléo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Legido-Quigley C, Bertram L, Barkhof F, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Lovestone S. (2020) Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer’s Disease Multimodal Biomarker Discovery Cohort. J Alzheimers Dis. 74(1):213-225.
Göthlin M, Eckerström M, Lindwall M, Rolstad S, Eckerström C, Jonsson M, Kettunen P, Svensson J, Wallin A. (2020) Latent Cognitive Profiles Differ Between Incipient Alzheimer’s Disease and Dementia with Subcortical Vascular Lesions in a Memory Clinic Population. J Alzheimers Dis. 73(3):955-966.
Eckerström C, Eckerström M, Göthlin M, Molinder A, Jonsson M, Kettunen P, Svensson J, Rolstad S, Wallin A. (2020) Characteristic biomarker and cognitive profile in incipient mixed dementia. J Alzheimers Dis. 73(2):597-607.
Kettunen P. (2020) Calcium Imaging in the Zebrafish. Adv Exp Med Biol. 1131:901-942.
Stamate D, Kim M, Proitsi P, Westwood S, Baird A, Nevado-Holgado A, Hye A, Bos I, Vos SJB, Vandenberghe R, Teunissen CE, Kate MT, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck E, Engelborghs S, Sleegers K, Bordet R, Ramit L, Kettunen P, Tsolaki M, Verhey F, Alcolea D, Lléo A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Legido-Quigley C. (2019) A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort. Alzheimers Dement (N Y). 5:933-938.
Shi L, Westwood S, Baird AL, Winchester L, Dobricic V, Kilpert F, Hong S, Franke A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Buckley NJ, Kate MT, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleó A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frölich L, Legido-Quigley C, Barkhof F, Blennow K, Zetterberg H, Baker S, Morgan BP, Streffer J, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ. (2019) Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay. Alzheimers Dement. 15(11):1478-1488.
Kim M, Snowden S, Suvitaival T, Ali A, Merkler DJ, Ahmad T, Westwood S, Baird A, Proitsi P, Nevado-Holgado A, Hye A, Bos I, Vos S, Vandenberghe R, Teunissen C, Ten Kate M, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck E, Sleegers K, Bordet R, Rami L, Kettunen P, Tsolaki M, Verhey F, Sala I, Lléo A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Engelborghs S, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Barkhof F, Ashton N, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Legido-Quigley C. (2019) Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer’s Disease biomarker discovery cohort. Alzheimers Dement. 15(6):817-827.
Morgan AR, Touchard S, Leckey C, O’Hagan C, Nevado-Holgado AJ; NIMA Consortium, Barkhof F, Bertram L, Blin O, Bos I, Dobricic V, Engelborghs S, Frisoni G, Frölich L, Gabel S, Johannsen P, Kettunen P, Kłoszewska I, Legido-Quigley C, Lleó A, Martinez-Lage P, Mecocci P, Meersmans K, Molinuevo JL, Peyratout G, Popp J, Richardson J, Sala I, Scheltens P, Streffer J, Soininen H, Tainta-Cuezva M, Teunissen C, Tsolaki M, Vandenberghe R, Visser PJ, Vos S, Wahlund LO, Wallin A, Westwood S, Zetterberg H, Lovestone S, Morgan BP; Annex: NIMA–Wellcome Trust Consortium for Neuroimmunology of Mood Disorders and Alzheimer’s Disease. (2019) Inflammatory biomarkers in Alzheimer’s disease plasma. Alzheimers Dement. 15(6):776-787.
Göthlin M, Eckerström M, Rolstad S, Kettunen P, Wallin A. (2018) Better prognostic accuracy in younger mild cognitive impairment patients with more years of education. Alzheimers Dement (Amst). 10:193.
Bos I, Vos SJB, Jansen WJ, Vandenberghe R, Gabel S, Estanga A, Ecay-Torres M, Tomassen J, den Braber A, Lleó A, Sala I, Wallin A, Kettunen P, Molinuevo JL, Rami L, Chetelat G, de la Sayette V, Tsolaki M, Freund-Levi Y, Johannsen P; Alzheimer’s Disease Neuroimaging Initiative, Novak GP, Ramakers I, Verhey FR, Visser PJ. (2018) Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data. Front. Aging Neurosci. 10:193.
Wallin A, Román GC, Esiri M, Kettunen P, Svensson J, Paraskevas GP, Kapaki E. (2018) Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease. J Alzheimers Dis. 62(3):1417-1441.
Wallin A, Kettunen P, Johansson PM, Jonsdottir I, Nilsson C, Nilsson M, Eckerström M, Nordlund A, Nyberg L, Sunnerhagen K, Svensson J, Terzis B; Wahlund, L-O, Kuhn G (2018) Cognitive medicine – a new approach in health care science. BMC Psychiatry 18(1):42.
Agholme L, Clarin M, Gkanatsiou E, Kettunen P, Chebli J, Brinkmalm G, Blennow K, Bergström P, Portelius E, Zetterberg H. (2017) Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ. Mol Cell Neurosci. 85:211-219.
Farnsworth B, Radomska KJ, Zimmermann B, Kettunen P, Jazin E, Emilsson LS. (2017) QKI6B mRNA levels are upregulated in schizophrenia and predict GFAP expression. Brain Res. 1669:63-68.
Wenger A, Larsson S, Danielsson A, Juul Elbæk K, Kettunen P, Tisell M, Sabel M, Lannering B, Nordborg C, Schepke E, Caren H. (2017) High-grade Pediatric Brain Tumor in vitro Cultures of Stem Cells mimic the Originating Tumor. Oncotarget. 8:18626-18639.
Zettergren A, Karlsson SA, Studer E, Sarvimäki A, Kettunen P, Thorsell A, Sihlbom C, Westberg L. (2017) Proteomic analyses of limbic regions in neonatal male, female and androgen receptor knockout mice. BMC Neurosci. 18: 9. doi:10.1186/s12868-016-0332-1.
Andersson C-H, Hansson O, Minthon L, Andreasen N, Blennow K, Zetterberg H, Skoog I, Wallin A, Nilsson S, Kettunen P. (2016) A genetic variant of the sortilin 1 gene is associated with reduced risk of Alzheimer’s disease. Journal of Alzheimer’s Disease. 53(4):1353-63.
Farnsworth B, Peuckert C, Zimmermann B, Jazin E, Kettunen P, Emilsson LS (2016) Gene expression of quaking in sporadic Alzheimer’s disease patients is both upregulated and related to expression levels of genes involved in amyloid plaque and neurofibrillary tangle formation. Journal of Alzheimer’s Disease. 53(1):209-19.
Banote RK, Edling M, Eliassen F, Kettunen P, Zetterberg H and Abramsson A (2016) β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner. Developmental Biology. 413(1):26-38.
Karlsson SA, Studer E, Kettunen P and Westberg L (2016) Neural androgen receptors modulate gene expression and social recognition but not social investigation. Frontiers in Behavioral Neuroscience 10:41.
Radomska K.J., Sager J., Farnsworth B., Tellgren-Roth Å., Tuveri G., Peuckert C., Kettunen P., Jazin E., Emilsson L.S. (2016) Characterization and Expression of the Zebrafish qki Paralogs. PLoS One. 11(1):e0146155.
Karlsson, S. A., Haziri, K., Hansson, E., Kettunen, P., Westberg L. (2015) Effects of sex and gonadectomy on social investigation and social recognition in mice. BMC Neurosci. 16(1):83
Bliman D., Nilsson J.R., Kettunen P., Andréasson J., Grøtli M. (2015) A Caged Ret Kinase Inhibitor and its Effect on Motoneuron Development in Zebrafish Embryos. Scientific Reports. 5:13109.
Kettunen P., Larsson S., Holmgren S., Olsson S., Minthon L., Zetterberg H., Blennow K., Nilsson S., Sjölander, A. (2015) Genetic Variants of GSK3B are Associated with Biomarkers for Alzheimer’s Disease and Cognitive Function. J Alzheimers Dis. 44(4):1313-22. (Corresponding author)
Abramsson, A., Kettunen, P., Lott, E., Li, M., Arnér A., and Zetterberg, H. (2013) The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation. Developmental Biology 381:377–388.
Landgren, S., von Otter, M., Nilsson S., Seibt Palmér, M., Lundvall, C., Lennart Minthon, L., Bogdanovic, N., Andreasen, N., Gustafson, D.R., Skoog, I., Wallin, A., Blennow, K., Zetterberg, H. and Kettunen P. (2012) A novel ARC gene polymorphism is associated with reduced risk of Alzheimer’s disease. Journal of Neural Transmission 119(7):833-42. (Corresponding author)
Kettunen, P. (2012) Calcium imaging in the zebrafish. Advances in Experimental Medicine and Biology 740:1039-71.
Issa F.A., O’Brien G., Kettunen P., Sagasti A., Glanzman D.L., and Papazian D.M. (2011) Neural Circuit Activity in Freely-Behaving Zebrafish (Danio rerio). Journal of Experimental Biology 214, 1028-1038.
Abramsson, A., Westman-Brinkmalm, A., Pannee, J., Gustavsson, M., von Otter, M., Blennow, K., Brinkmalm, G., Kettunen, P., and Zetterberg, H. (2010) Proteomic profiling of single organs from individual adult zebrafish. Zebrafish 7(2):161-8.
Neveu, P., Sinha, D., Kettunen, P., Vriz, S., Julien, L. and Bensimon D. (2010) Single cell physiology. In: Proceedings of the Nobel Symposium on “Single Molecule Spectroscopy in Chemistry, Physics and Biology”, ed. R. Rigler and J. Widengren. Vol 96. P. 305-316.
Nanou, E., Kyriakatos A., Kettunen, P., and El Manira, A. (2009) Separate signaling mechanisms underlie mGluR1 modulation of leak channels and NMDA receptors in the network underlying locomotion. Journal of Physiology 587:3001-8.
Kettunen, P., Kyriakatos, A., Hallén, K. and El Manira, A. (2005) Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network. Neuron 45:95-104.
Hallén, K., Huss, M., Kettunen, P., El Manira, A., and Hellgren-Kotaleski, J. (2004) mGluR-mediated calcium oscillations in the lamprey: a computational model. Neurocomputing 58-60:431-435.
Kettunen, P., Krieger, P., Hess, D. and El Manira, A. (2003) mGluR1, but not mGluR5, mediates depolarization of spinal cord neurons by blocking a leak current. Journal of Neurophysiology 90:2341-2348.
Kettunen, P., Demas, J., Lohmann, C., Kasthuri, N., Gong, Y., Wong, R.O.L. and Gan, W-B. (2002) Calcium dynamics in the nervous system by means of ballistic delivery of indicators. Journal of Neuroscience Methods 119:37-43.
Kettunen, P., Krieger, P., Hess, D. and El Manira A. (2002) Signalling mechanisms of metabotropic glutamate receptor 5 subtype and its endogenous role in a locomotor network. Journal of Neuroscience 22:1868-1873.
El Manira A., Kettunen, P., Hess, D. and Krieger, P. (2002) Metabotropic glutamate receptors provide intrinsic modulation of the lamprey locomotor network. Brain Research Reviews 40:9-18.
Krieger, P., Hellgren-Kotaleski, J., Kettunen, P. and El Manira, A. (2000) Interaction between metabotropic and ionotropic glutamate receptors regulates neuronal network activity. Journal of Neuroscience 20:5382-53.